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KMID : 0606320010170010047
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Journal of Phamacetical Sciences Sookmyung Women s University
2001 Volume.17 No. 1 p.47 ~ p.52
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Effects of Phellinus linteus Extracts on the Proliferation of Lymphocytes in Mice
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Pyo Myoung-Yun
Hyun Su-Mi
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Abstract
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The effects of Phellinus linteus hot water extract (PL-W) and methanol extract (PL- M) on the normal splenocytes proliferation (SP) and cyclophosphamide (CY)-induced suppression of SP were investigated in vitro by MTT assay. When mouse splenocytes were exposed to PL-W or PL-M, SP was significantly increased. Also, SP to the mitogen, concanavalin A (Con A) and lipopolysaccharide (LPS) were significantly and dose- dependently increased by PL-W and PL-M. The concomitant treatment of CY with PL-W or PL-M increased splenic T cells and B cells proliferation compared with only CY treatment. Especially, these activates were higher by PL-M than by PL-W. These results suggest that Phellinus linteus extracts have mitogenic effects on splenocytes, and activity to inhibit immunotoxicity induced by CY.
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KEYWORD
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